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However, testosterone in physiologic doses might even be useful in patients with angina , have larger ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood move in men with established coronary artery illness . Therefore, an interplay of endogenous factors of the patient’s threat profile in addition to the testosterone dosing could additionally be issues of whether or not antagonistic events occur. Erythrocytosis has been reported as a possible impact of testosterone, which may be useful in patients with anemia.
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Patients additionally may be taking concomitant stimulants, similar to ephedra, which might confound data and the potential for antagonistic occasions. It is likely that the frequency of cardiac occasions is underreported within the medical literature. Moreover, testosterone has been used in the therapy of reduced muscle mass and bone density as nicely as anemia. The position testosterone might play in the development of heart problems has increasingly become the subject of current interest . Supraphysiologic doses of anabolic-androgenic steroids , which include more than 30 pure and artificial derivatives of testosterone, could trigger a large spectrum of medical sequalae. Supplemental or physiologic doses of testosterone have seen expanded use in medical practice recently. Other common potential adverse results embody infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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We report a case of an acute ST-segment elevation myocardial infarction in a affected person with traditional cardiac threat components using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person also had polycythemia, probably secondary to high-dose testosterone. The patient underwent successful percutaneous intervention of the proper coronary artery. Physicians and sufferers should pay attention to the clinical consequences of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which may contribute to abnormal vessel reactivity.
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Anabolic Steroids, Acute Myocardial Infarction And Polycythemia: A Case Report And Review Of The Literature
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